Renal Denervation and Celiac Ganglionectomy Decrease Mean Arterial Pressure Similarly in Genetically Hypertensive Schlager (BPH/2J) Mice

Renal denervation (RDNX) lowers mean arterial pressure (MAP) in patients with resistant hypertension. Less well studied is the effect of celiac ganglionectomy (CGX), a procedure which involves removal nerves innervating splanchnic vascular bed. We hypothesized that RDNX and CGX would both lower MAP genetically hypertensive Schlager (BPH/2J) mice through reduction sympathetic tone. Telemeters were implanted into femoral artery to monitor before after (n=5), (n=6), or SHAM (n=6). MAP, systolic blood pressure, diastolic heart rate recorded for 14 days postoperatively. The response hexamethonium (10 mg/kg, IP) was measured on control day 3 postoperative 10 as measure global neurogenic pressor activity. efficacy assessed by measurement tissue norepinephrine. Control similar among groups surgical treatments (≈130 mm Hg). On 14, significantly (−11±2 Hg) (−11±1 compared their predenervation values. This not case (−5±3 depressor group smaller (−10±5 baseline (−25±10 (day 10; −28±5 −34±7 group. In conclusion, renal contribute hypertension BPH/2J mice, but likely different mechanisms.